From: Subject: Neutering: Myths and New Realities Date: Tue, 16 Aug 2005 13:57:14 -0700 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01C5A26A.6836EBB0" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.2180 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C5A26A.6836EBB0 Content-Type: text/html; charset="Windows-1252" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.neutersol.com/Neutering%20Myths%20and%20New%20Realities.htm Neutering: Myths and New Realities










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For Immediate=20 = Release:          &n= bsp;    =20

Neutering: Myths and New = Realities
by Don=20 P. Polley, DVM

          =  =20 Contemporary clinical data has revealed the actual science = of canine=20 neutering and its affect on behavior, testosterone, = testicular=20 cancer and prostrate enlargement is significantly changing=20 traditional views on this topic.=20 =
           =20 As with any new technology or approach that appears on the = scene,=20 the advent of the recently FDA approved = Neutersol=AE=20 injectable sterilant for neutering male puppies ages 3 - 10 = months=20 inspires the veterinarian community to re-examine the = thinking on=20 neutering based on new information. Neutersol and its = supporting=20 clinical studies and post-study data demonstrate that this = new=20 approach effectively answers some age-old = questions.

What=20 is Neutersol=AE?=20 =

          &= nbsp;=20 Neutersol=AE (zinc gluconate neutralized = by=20 arginine) is injected into a specific location in each of = the young=20 dog=92s testicles with a 28 gauge needle as the puppy lies = on its back=20 on the exam table. This fine needle coupled with the = visceral nature=20 of testicular enervation accounts for the minimal degree of=20 objection to the procedure, even in the non-sedated puppy = (97% did=20 not object to the injection). In some instances, especially = with=20 first few dogs injected, sedation may be used to avoid = movement.=20 Neutersol produces sterility by causing atrophy of the = testes,=20 epididymis, and prostate. Side effects, if any, are minor. = Mild,=20 transient testicular swelling which subsides within a day or = two may=20 be seen.=20 =
           =20 The procedure is brief, at most five or six minutes (less = than 1=20 minute veterinary time), and the puppy may be released from = a few=20 minutes to several hours post- injection. Using the = injection=20 approach avoids the risks of anesthesia, the discomfort of = clipper=20 irritation, and an incision with sutures to stimulate post = operative=20 self- mutilation. The need for overnight stays and follow up = appointments is eliminated.

Addressing The = Testosterone=20 = Issue

         &n= bsp; =20 Testosterone plays a role in modulating certain behaviors = such as=20 roaming, urine marking in-doors, sexual mounting and = aggression=20 toward other dogs (versus playful activity or dominance). = Neutersol=20 reduces the male hormone, testosterone, by 41-52% while = surgical=20 castration reduces testosterone by 95%. These behaviors may = persist=20 after either neutering method.=20 =
           =20 While testosterone plays a role in affecting certain = sexually=20 dimorphic behaviors, it is not the only factor. In fact, the = veterinary behavioral textbooks point out that there are = multiple=20 contributing factors with regard to these behaviors. = Surgical=20 castration does not completely eliminate these behaviors. = The=20 controlled scientific studies that have assessed the effects = of=20 surgical castration with regard to behavior have shown that = most=20 dogs continue exhibiting these behaviors. Aggression toward = humans=20 shows little significant effect after surgical castration. = Surgery=20 can have an effect in some of these, but is far from = absolute. The=20 FDA has reviewed the data for both surgery and Neutersol and = included wording in the prescribing information of = Neutersol=20 addressing this fact, "As with surgical castration, = secondary=20 male characteristics (roaming, marking, aggression and = mounting) may=20 persist."
(For a complete review of the literature, = visit: http://www.neuter= sol.com/TestosteroneFacts.htm).

Dispelling Testicular Cancer=20 = Concerns

         = ;  =20 Testicular cancers are rare to begin with. Male dogs have a = lifetime=20 prevalence of 0.9% of testicular cancers. Most of the time = these are=20 benign and/or microscopic and not problematic. Neutersol = produces=20 atrophy of the seminiferous tubule which contain the 2 cell = types=20 responsible for 2 of the 3 most prevalent testicular = cancers,=20 Sertoli cell tumor and seminoma. This action raises the = question: if=20 there are no cells to develop the cancer, what is the = likelihood of=20 it occurring?=20 =
           =20 Actually, the highest prevalence of testicular cancers = occurs in=20 dogs that have undescended testicles (cryptorchid). = Neutersol is not=20 indicated in puppies with this condition.  Given a 0.9% = testicular cancer rate among male dogs, minus most of those = because=20 they prove to be benign and non-problematic, reduced further = by=20 atrophy of cell types responsible for cancer of the testes, = and=20 finally eliminating the subset of patients most likely to = develop=20 testicular tumors (cryptorchids), would result in a very = low,=20 virtually insignificant rate of testicular cancer.=20 =
           =20 Veterinarians presented with this information have concluded = the=20 perceived risk of this cancer is not a concern.

Correcting Inaccurate Prostrate Cancer = and=20 Enlargement Perceptions=20 =

          &= nbsp;=20 Veterinarians who graduated more than 10 years ago were = taught that=20 prostate cancer is more prevalent in intact dogs than = castrated=20 dogs. Prostate cancer is actually more common in castrated = dogs than=20 intact ones. Contemporary veterinary textbooks and peer = reviewed=20 literature stress that prostate cancer in dogs is hormonally = independent and that castrated dogs have shown up to a four = times=20 greater risk of developing prostate cancer than intact dogs. = =
           =20 The inaccuracy likely began because there was no data in = dogs 30=20 years ago before the advocacy of spay/neutering. In the = absence of=20 that data, veterinary practitioners borrowed data from human = medicine. As it is well known now, significant differences = exist=20 between the human and canine species. As a result, = veterinarians=20 have to set aside prostate cancer as a concern with = Neutersol versus=20 surgical castration.=20 =
           =20 The enlargement of the prostate due to benign prostatic = hyperplasia=20 (BPH) as dogs age raises a concern among veterinarians This=20 enlargement can lead to secondary problems and is = testosterone=20 dependent. An enlarging prostate pushes on other organs, = such as the=20 colon, and disrupts their function, making it difficult to = have a=20 bowel=20 = movement.
          =  =20 Two important things to keep in mind here. One, although = nearly 100%=20 of intact male dogs past the age of nine will have an = enlarged=20 prostate, only 1.5% of male dogs will present with symptoms = due to=20 that=20 = enlargement.
         &nb= sp; =20 Secondly, when the prostate in aging men enlarges, it grows = inward=20 impinging upon the urethra and making it difficult to = urinate. In=20 dogs, the prostate enlarges outward to push against the = colon, with=20 significantly more expansion room outward, which explains = the lower=20 prevalence of developing secondary urinary problems in = canines.=20 =
           =20 The real issue to consider, though, is that Neutersol = actually=20 shrinks the prostate significantly. Two years post- = injection,=20 Neutersoled dogs had a 52% smaller prostate on average than = the=20 control dogs. Even if the prostate stays its normal size, or = grows=20 slightly, secondary problems are not likely to develop. = Neutersol=20 goes even further to reduce this likelihood by significantly = shrinking the prostate.

Towards New=20 = Understandings

        &nb= sp;  =20 Undoing commonly held beliefs is not an easy task, but = history=20 and science have shown that we do not live on a flat planet. = Though=20 the first scientists to proclaim otherwise were labeled = heretics, we=20 sometimes find that today's heretics are tomorrow's = prophets.=20 =
           =20 Supported by science, more accurate and up-to-date findings = replace=20 these common misconceptions and myths concerning = neutering=92s=20 effects, be it surgical or by injection. In presenting = neutering=20 choices to clients for their puppies, veterinarians can be = confident=20 that Neutersol virtually eliminates the puppy=92s surgical = risks with=20 the same net effect while ensuring the comfort and same-day = return=20 home with the owner.=20 =
           =20 Fresh thinking and openness to new technology works to the = clients=92=20 benefit and
positions the veterinarian as an informed = guardian=20 of their pets=92 health.

-------------------------

Don P. Polley, DVM, is Director of = Veterinary Services=20 Neutersol (http://www.neutersol.com/)=20
with Addison Biological Laboratory, Inc., based in = Fayette,=20 Missouri. He was President and Chief-of-Staff of Harvester = Animal=20 Clinic, St. Charles, Missouri, and is an author, lecturer, = and=20 consultant on Practice Management. He recently served as = Director=20 Veterinary Services Emergency Animal Rescue Service, United = Animal=20 Nations. He can be reached at 1-800-331-2530; email: don@neutersol.com. =

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